TECHNOLOGY
HETERPOLYMER PUBLICATIONS
Repik, A, Pincus, S.E., Ghiran, I., Nicholson-Weller, A., Asher, D.R. , Cerny, A., Casey, L.S. , Jones, S.M. ,. Jones, S.N. , Mohamed, N., Klickstein, L.B., Spitalny, G.S., Finberg, R.W., (2005) A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1) Clinical and Experimental Immunology,140: 230–240
Mohamed, N, Jones, SM, Casey, LS, Pincus, SE and Spitalny, GL. Heteropolymers: A novel technology against blood-borne infections. (2005) Current Opinion in Molecular Therapeutics 7:144-150
Pincus, S. Heteropolymers: A New Class of Therapeutics for Treating Lethal Bacterial and Viral Infections (Abstract) (Pathogen Countermeasures/Accelerated Anthrax PI meeting (DARPA) Ft Lauderdale Fl., March 9-11, 2005)
S. E. Pincus, T.A. Bradley, X. Chen, S. M. Jones, T. Kim, R. M. Buller, N. Bourne, P. Mason Heteropolymers: a New Class of Therapeutics for Prophylactics of Viral Infections (Abstract) (2005 ASM Biodefense Research Meeting,Baltimore MD, March 20-23, 2005)
Iking-Konert, C., Stocks, S., Weinsberg, F. Engelbrecht, R., Bleck, E., Perniok, A., Fisher-Betz, R., Pincus, S., Nardone, L., and Schneider, M. (2004) First Clinical Trials of a New Heteropolymer Technology Agent in Normal Healthy Volunteers and Patients with systemic Lupus Erythematosus. Ann Rheum Dis 63: 1104-1112.
Mohamed, N., Jones, S.M., Li, J., Ferreira, C., Chen, X., Kreiswirth, B., Casey, L.S., Spitalny, G.L., Pincus, S. (2004) Heteropolymers: a New Class of Therapeutics for Treating Lethal Bacterial and Viral Infections. 2004 Scientific Conference for Chemical and Biological Defense Research (abstract)
Jones, S.M., Li, J., Ferreira, C.S., Shah, K., Lee, S., Pincus, S.E., Spitalny, G.L., Casey, L.S., Kreiswirth, B, Mohamed, N. (2004) Complete Protection against Staphylococcus aureus Bacteremia using a Novel Dual Antibody Therapeutic Approach. The 44th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), October 30th - Nov 2nd, 2004, Washington DC.
Jones, S.M., Li, J., Ferreira, C.S., Pincus, S.E., Casey, L.S., Kreiswirth, B, Mohamed, N. (2005) A novel therapeutic approach for treatment of bacterial biodefense agents. 2005 ASM Biodefense Research Meeting, March 20th-23rd,2005, Baltimore MD.
M. L. Craig, A. J. Bankovich, R. P. Taylor, “Visualization of the Transfer Reaction: Tracking Immune Complexes from Erythrocyte Complement Receptor 1 to Macrophages”, Clinical Immunology (2002), Vol. 105, No. 1, October, pp.36-47
M. Lindorfer, A. Nardin, P. Foley, M. Solga, A. Bankovich, E. Martin, A. Henderson,
C. Price, E. Cyimesi, C. Wozencraft, J. Goldberg, W. Sutherland, R. P. Taylor, “Targeting of Pseudomonas Aeruginosa in the Bloodstream with Bispecific Monoclonal
Antibodies”, The Journal of Immunology (2001), Vol. 167, pp. 2240-2249
C. Hahn, O. French, P. Foley, E. Martin, R. P. Taylor, “Bispecific Monoclonal Antibodies Mediate Binding of Dengue Virus to Erythrocytes in a Monkey Model of Passive Viremia”, The Journal of Immunology (2001), Vol. 166, pp. 1057-1065
M. L. Reinagel, R. P. Taylor, “Transfer of Immune Complexes from Erythrocyte CR1 to Mouse Macrophages”, The American Association of Immunologists (2000), Vol. 0022 –1767, pp. 1977-1985
A.Nardin, M. Lindorfer, R. P. Taylor, “How are Immune Complexes Bound to the Primate Erythrocyte Complement Receptor Transferred to Acceptor Phagocytic Cells?”,Molecular Immunology (1999), Vol. 36, pp. 827-835
A. Nardin, R. Schlimgen, V. M. Holers, R. P. Taylor, “A Prototype Pathogen Bound Ex Vivo to Human Erythrocyte Complement Receptor 1 Via Bispecific Monoclonal Antibody Complexes is Cleared to the Liver in a Mouse Model”, European Journal of Immunology (1999), Vol. 29, pp. 1581-1586
M. Craig, M. Reinagel, E. N. Martin, R. Schlimgen, A. Nardin, R. P. Taylor, “Infusion of Bispecific Monoclonal Antibody Complexes into Monkeys Provides Immunologic Protection Against Later Challenge with a Model Pathogen”, Clinical Immunology (1999), Vol. 92, No. 2, pp. 170-180
A. Nardin, W. M. Sutherland, M. Hevey, A. Schmaljohn, R. P. Taylor, “Quantitative Studies of Heteropolymer-Mediated Binding of Inactivated Marburg Virus to the Complement Receptor on Primate Erythrocytes”, Journal of Immunological Methods (1998), Vol. 211, pp.21-31
S. E. Kuhn, A. Nardin, P. E. Klebba, R. P. Taylor, “Escherichia Coli Bound to the Primate Erythrocyte Complement Receptor Via Bispecific Monoclonal Antibodies are Transferred to and Phagocytosed by Human Monocytes in an In Vitro Model”, The Journal of Immunology (1998), Vol. 160. p. 5088-5097
R. P. Taylor, E. N. Martin, M. L. Reinagel, A. Nardin, M. Craig, Q. Choice, R. Schlimgen, S. Greenbaum, N. L. Incardona, H. D. Ochs, “Bispecific Monoclonal Antibody Complexes Facilitate Erythrocyte Binding and Liver Clearance of a Prototype Particulate Pathogen in a Monkey Model”, The Journal of Immunology (1997), Vol. 159,pp. 4035-4044
R. P. Taylor, W. M. Sutherland, E. N. Martin, P. J. Ferguson, M. L. Reinagel, E. Gilbert, K. L. Lopez, N. L. Incardona, H. D. Ochs, “Bispecific Monoclonal Antibody Complexes Bound to Primate Erthrocyte Complement Receptor 1 Facilitate Virus Clearance in a Monkey Model”, The Journal of Immunology (1997), Vol. 158, pp. 842-850
M. L Reinagel, M. Gezen, P. J. Ferguson, S. Kuhn, E. N. Martin, R. P. Taylor, “The Primate Erythrocyte Complement Receptor (CR1) as Privileged Site: Binding of Immunoglobulin G to Erythrocyte CR1 Does Not Target Erythrocytes for Phagocytosis”, Blood (1997), Vol. 89, No. 3, pp. 1068-1077
R. P. Taylor, W. M. Sutherland, C. J. Reist, D. J. Webb, E. L. Wright, R. H. Labuguen, “Use of Heteropolymeric Monoclonal Antibodies to Attach Antigens to the C3b Receptor of Human Erythrocytes: A Potential Therapeutic Treatment”, Proceedings of the National Academy of Science (1991), Vol. 88, pp. 3305-3309